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F-actin is labelled with Texas Red-x phalloidin. Blue nuclear staining with DAPI. Imaged on the Spinning Disk Confocal microscope. Bottom Immunostaining demonstrating blood vessels surrounding a tumour. Glut1 immunostaining red specifically labels veinous structures whereas arterial structures are Glut1 negative. Red blood cells in the vessels were detected by inherent autofluorescence green and cell nuclei were labelled with DAPI blue. It has been a particularly important year with the completion of the Institute s Quinquennial Review but also with the initiation of the new Drug Discovery Centre. In return the Institute has to ensure that it is undertaking research of the highest international quality and that the research that we do will impact significantly towards achievement of CR-UK s major research goals as outlined in their 5-year strategic plan. There are a number of ways of measuring our success which includes periodic review of all the research programmes. However, perhaps the most important process is the Quinquennial Institute Review which is commissioned by CR- UK and involves assembling a team of worldleading scientists experienced in running research organisations or institutes.

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